![]() ![]() Results: It indicated time‑ and dose‑dependent anti‑invasive and antimigrative or proliferative and antitoxic effects of hydroalcoholic extract of aerial parts of chamomile on breast cancer cells. Furthermore, increasing the extract concentrations induced cellular apoptosis and necrosis and decreased cellular invasion or migration through 8 μm pores, colonization and attachment in a dose‑dependent manner. This study quantified the 50% growth inhibition concentrations (IC 50) by 3‑(4,5‑dimethylthiazol‑2‑yl)‑2,5‑diphenyltetrazolium bromide assay apoptosis and necrosis through Hoechst 33342/propidium iodide staining cell proliferation and clone formation by clonogenic assay as well as cellular migration, invasion, and attachment. chamomilla at different concentrations (50–1300 μg/mL) for 24, 48, and 72 h in a culture medium containing 10% fetal bovine serum. Materials and Methods: The cells were treated with hydroalcoholic extract of M. chamomilla on human breast cancer MCF‑7 and MDA‑MB‑468 cell lines. gThis study investigated the methods to evaluate these anticancer mechanisms of M. chamomilla on migration and invasion of human breast cancer cells remains unclear. Background: Matricaria chamomilla is an aromatic plant with antioxidant, anticancer, and anti‑inflammatory properties. ![]()
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